4MRC

Human Transthyretin Ser52Pro Mutant

Summary for 4MRC

• Entry DOI: 10.2210/pdb4mrc/pdb
• Related: 4MRB
• Descriptor: Transthyretin, CALCIUM ION (3 entities in total)
• Functional Keywords: hormone transporter, thyroxine t4, transport protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 27540.85

Authors

Chen, W.J.,Wood, S.P. (deposition date: 2013-09-17, release date: 2014-01-08, Last modification date: 2024-02-28)

• Primary citation: Mangione, P.P.,Porcari, R.,Gillmore, J.D.,Pucci, P.,Monti, M.,Porcari, M.,Giorgetti, S.,Marchese, L.,Raimondi, S.,Serpell, L.C.,Chen, W.,Relini, A.,Marcoux, J.,Clatworthy, I.R.,Taylor, G.W.,Tennent, G.A.,Robinson, C.V.,Hawkins, P.N.,Stoppini, M.,Wood, S.P.,Pepys, M.B.,Bellotti, V.; Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.; Proc.Natl.Acad.Sci.USA, 111:1539-1544, 2014; PubMed: 24474780; DOI: 10.1073/pnas.1317488111

Experimental method

X-RAY DIFFRACTION (1.54 Å)