4MRB
Wild Type Human Transthyretin pH 7.5
Summary for 4MRB
Entry DOI | 10.2210/pdb4mrb/pdb |
Related | 4MRC |
Descriptor | Transthyretin, CALCIUM ION (3 entities in total) |
Functional Keywords | hormone transporter, thyroxine t4, transport protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 27634.88 |
Authors | Chen, W.J.,Wood, S.P. (deposition date: 2013-09-17, release date: 2014-01-08, Last modification date: 2024-02-28) |
Primary citation | Mangione, P.P.,Porcari, R.,Gillmore, J.D.,Pucci, P.,Monti, M.,Porcari, M.,Giorgetti, S.,Marchese, L.,Raimondi, S.,Serpell, L.C.,Chen, W.,Relini, A.,Marcoux, J.,Clatworthy, I.R.,Taylor, G.W.,Tennent, G.A.,Robinson, C.V.,Hawkins, P.N.,Stoppini, M.,Wood, S.P.,Pepys, M.B.,Bellotti, V. Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. Proc.Natl.Acad.Sci.USA, 111:1539-1544, 2014 Cited by PubMed: 24474780DOI: 10.1073/pnas.1317488111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.27 Å) |
Structure validation
Download full validation report