4MR8

Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist CGP35348

4MR8 の概要

• エントリーDOI: 10.2210/pdb4mr8/pdb
• 関連するPDBエントリー: 4MQE 4MQF 4MR7 4MR9 4MRM 4MS1 4MS3 4MS4
• 分子名称: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: heterodimeric protein complex, venus flytrap module, neurotransmitter receptor, signaling protein-antagonist complex, signaling protein/antagonist
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98684.93

構造登録者

Geng, Y.,Bush, M.,Mosyak, L.,Wang, F.,Fan, Q.R. (登録日: 2013-09-17, 公開日: 2013-12-11, 最終更新日: 2023-09-20)

• 主引用文献: Geng, Y.,Bush, M.,Mosyak, L.,Wang, F.,Fan, Q.R.; Structural mechanism of ligand activation in human GABA(B) receptor.; Nature, 504:254-259, 2013; PubMed: 24305054; DOI: 10.1038/nature12725

実験手法

X-RAY DIFFRACTION (2.15 Å)