4MR7

Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist CGP54626

Summary for 4MR7

• Entry DOI: 10.2210/pdb4mr7/pdb
• Related: 4MQE 4MQF 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4
• Descriptor: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: heterodimeric protein complex, venus flytrap module, neurotransmitter receptor, signaling protein-antagonist complex, signaling protein/antagonist
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 99192.29

Authors

Geng, Y.,Bush, M.,Mosyak, L.,Wang, F.,Fan, Q.R. (deposition date: 2013-09-17, release date: 2013-12-11, Last modification date: 2023-09-20)

• Primary citation: Geng, Y.,Bush, M.,Mosyak, L.,Wang, F.,Fan, Q.R.; Structural mechanism of ligand activation in human GABA(B) receptor.; Nature, 504:254-259, 2013; PubMed: 24305054; DOI: 10.1038/nature12725

Experimental method

X-RAY DIFFRACTION (2.15 Å)