4MQU

Human GKRP complexed to AMG-3969 and S6P

4MQU の概要

• エントリーDOI: 10.2210/pdb4mqu/pdb
• 関連するPDBエントリー: 4MRO
• 分子名称: Glucokinase regulatory protein, 2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: sis domains, regulatory protein, binds fructose phosphates and glucokinase, transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): Q14397
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 145479.10

構造登録者

St Jean, D.J.,Ashton, K.S.,Bartberger, M.D.,Chen, J.,Chmait, S.,Cupples, R.,Galbreath, E.,Helmering, J.,Jordan, S.R.,Liu, L. (登録日: 2013-09-16, 公開日: 2014-05-07, 最終更新日: 2024-04-03)

• 主引用文献: St Jean, D.J.,Ashton, K.S.,Bartberger, M.D.,Chen, J.,Chmait, S.,Cupples, R.,Galbreath, E.,Helmering, J.,Hong, F.T.,Jordan, S.R.,Liu, L.,Kunz, R.K.,Michelsen, K.,Nishimura, N.,Pennington, L.D.,Poon, S.F.,Reid, D.,Sivits, G.,Stec, M.M.,Tadesse, S.,Tamayo, N.,Van, G.,Yang, K.C.,Zhang, J.,Norman, M.H.,Fotsch, C.,Lloyd, D.J.,Hale, C.; Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.; J.Med.Chem., 57:325-338, 2014; PubMed: 24405213; DOI: 10.1021/jm4016747

実験手法

X-RAY DIFFRACTION (2.22 Å)