4MQA
Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)
Summary for 4MQA
Entry DOI | 10.2210/pdb4mqa/pdb |
Related | 4MPU 4MPV 4MPW 4MPX |
Descriptor | Tryptase alpha/beta-1, SULFATE ION, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | coferon, alpha-hydroxyketone, small molecule inhibitor, drug discovery, self-assembly, crystal catalysis, silanol, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: Q15661 |
Total number of polymer chains | 2 |
Total formula weight | 56468.65 |
Authors | |
Primary citation | Giardina, S.F.,Pingle, M.,Foreman, K.W.,Werner, D.S.,Bergstrom, D.E.,Barany, F.,Arnold, L.D. Target-directed self-assembly of homodimeric drugs To be Published, |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
Download full validation report