4MQA
Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tryptase alpha/beta-1 | polymer | 245 | 27491.4 | 2 | UniProt (Q15661) Pfam (PF00089) | Homo sapiens (human) | Tryptase-1, Tryptase I, Tryptase alpha-1 |
| 2 | C, E, G, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | D (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | F (B) | {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone) | non-polymer | 811.3 | 1 | Chemie (X00) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 275 (UniProt: Q15661)
| PDB | External Database | Details |
|---|---|---|
| Lys 132 | Asn 132 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54982.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1485.8 | |
| All* | Total formula weight | 56468.7 |
