4MPW
Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzofuran-3,5-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)
Summary for 4MPW
Entry DOI | 10.2210/pdb4mpw/pdb |
Related | 4MPU 4MPV 4MPX 4MQA |
Descriptor | Tryptase alpha/beta-1, CHLORIDE ION, TRIETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | coferon, alpha-hydroxyketone, small molecule inhibitor, drug discovery, self-assembly, crystal catalysis, silanol, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 56271.31 |
Authors | White, A.,Stein, A.J.,Suto, R. (deposition date: 2013-09-13, release date: 2015-03-18, Last modification date: 2024-10-09) |
Primary citation | Giardina, S.F.,Werner, D.S.,Pingle, M.,Bergstrom, D.E.,Arnold, L.D.,Barany, F. A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human beta-Tryptase. Pharmacology, 102:233-243, 2018 Cited by PubMed: 30134249DOI: 10.1159/000492078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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