4MPW
Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzofuran-3,5-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tryptase alpha/beta-1 | polymer | 245 | 27491.4 | 2 | UniProt (Q15661) Pfam (PF00089) | Homo sapiens (human) | Tryptase-1, Tryptase I, Tryptase alpha-1 |
| 2 | C, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, I (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 4 | E, G (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | F (B) | [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzofuran-3,5-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone) | non-polymer | 799.1 | 1 | Chemie (2AJ) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 421 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 275 (UniProt: Q15661)
| PDB | External Database | Details |
|---|---|---|
| Lys 132 | Asn 132 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54982.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1288.5 | |
| All* | Total formula weight | 56271.3 |
