4MNS

Crystal structure of the major pollen allergen Bet v 1-A in complex with P303

Summary for 4MNS

• Entry DOI: 10.2210/pdb4mns/pdb
• Descriptor: Major pollen allergen Bet v 1-A, (3R,4R,5aR,11aR)-3-methyl-6,11-dioxo-2,3,4,5,5a,6,11,11a-octahydrothiepino[3,2-g]isoquinoline-4-carboxylic acid (3 entities in total)
• Functional Keywords: major pollen allergen, allergen
• Biological source: Betula pendula (white birch)
• Cellular location: Cytoplasm: P15494
• Total number of polymer chains: 1
• Total formula weight: 17766.94

Authors

Leone, P.,Roussel, A. (deposition date: 2013-09-11, release date: 2015-03-11, Last modification date: 2023-09-20)

Primary citation

Nony, E.,Bouley, J.,Le Mignon, M.,Lemoine, P.,Jain, K.,Horiot, S.,Mascarell, L.,Pallardy, M.,Vincentelli, R.,Leone, P.,Roussel, A.,Batard, T.,Abiteboul, K.,Robin, B.,de Beaumont, O.,Arvidsson, M.,Rak, S.,Moingeon, P.
Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients.
Allergy, 70:795-804, 2015

PubMed Abstract: Sublingual immunotherapy (SLIT) applied to type I respiratory allergies is commonly performed with natural allergen extracts. Herein, we developed a sublingual tablet made of pharmaceutical-grade recombinant Bet v 1.0101 (rBet v 1) and investigated its clinical safety and efficacy in birch pollen (BP)-allergic patients.

PubMed: 25846209
DOI: 10.1111/all.12622

Experimental method

X-RAY DIFFRACTION (1.2 Å)