4MNB

Crystal Structure of a complex between the marine anticancer drug Variolin B and DNA

Summary for 4MNB

• Entry DOI: 10.2210/pdb4mnb/pdb
• Descriptor: 5'-D(*CP*GP*TP*AP*CP*G)-3', 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, COBALT HEXAMMINE(III), ... (6 entities in total)
• Functional Keywords: dna duplex, intercalation, drug binding, nucleus, dna
• Total number of polymer chains: 2
• Total formula weight: 4770.27

Authors

Canals, A.,Arribas-Bosacoma, R.,Alvarez, M.,Albericio, F.,Aymami, J.,Coll, M. (deposition date: 2013-09-10, release date: 2015-03-11, Last modification date: 2024-02-28)

Primary citation

Canals, A.,Arribas-Bosacoma, R.,Albericio, F.,Alvarez, M.,Aymami, J.,Coll, M.
Intercalative DNA binding of the marine anticancer drug variolin B.
Sci Rep, 7:39680-39680, 2017

PubMed Abstract: Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.

PubMed: 28051169
DOI: 10.1038/srep39680

Experimental method

X-RAY DIFFRACTION (1.4 Å)