4MM3

Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde

Summary for 4MM3

• Entry DOI: 10.2210/pdb4mm3/pdb
• Related: 1UBQ 2FE8
• Descriptor: Ubiquitin, Papain-like proteinase, ZINC ION, ... (4 entities in total)
• Functional Keywords: nsp3 papain-like protease domain, signaling protein-hydrolase complex, signaling protein/hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Ubiquitin: Cytoplasm : P0CG48; Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• Total number of polymer chains: 2
• Total formula weight: 44146.51

Authors

Mesecar, A.D.,Ratia, K. (deposition date: 2013-09-08, release date: 2014-07-02, Last modification date: 2017-11-15)

• Primary citation: Ratia, K.,Kilianski, A.,Baez-Santos, Y.M.,Baker, S.C.,Mesecar, A.; Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.; Plos Pathog., 10:e1004113-e1004113, 2014; PubMed: 24854014; DOI: 10.1371/journal.ppat.1004113

Experimental method

X-RAY DIFFRACTION (2.752 Å)