4MLK

3.05A resolution structure of CT584 from Chlamydia trachomatis

Summary for 4MLK

• Entry DOI: 10.2210/pdb4mlk/pdb
• Descriptor: CT584 protein (1 entity in total)
• Functional Keywords: ct584, chlamydia, hypothetical protein, unknown function
• Biological source: Chlamydia trachomatis
• Total number of polymer chains: 1
• Total formula weight: 22449.75

Authors

Hickey, J.,Lovell, S.,Kemege, K.,Barta, M.L.,Battaile, K.P.,Hefty, P.S. (deposition date: 2013-09-06, release date: 2013-11-13, Last modification date: 2024-02-28)

Primary citation

Barta, M.L.,Hickey, J.,Kemege, K.E.,Lovell, S.,Battaile, K.P.,Hefty, P.S.
Structure of CT584 from Chlamydia trachomatis refined to 3.05 angstrom resolution.
Acta Crystallogr.,Sect.F, 69:1196-1201, 2013

PubMed Abstract: Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic Chlamydiae spp. utilize a supramolecular syringe, or type III secretion system (T3SS), to inject proteins into their obligate host in order to propagate infection. Here, the structure of CT584, a T3SS-associated protein, that has been refined to a resolution of 3.05 Å is reported. The CT584 structure is a hexamer comprised of a trimer of dimers. The structure shares a high degree of similarity to the recently reported structure of an orthologous protein, Cpn0803, from Chlamydia pneumoniae, which highlights the highly conserved nature of this protein across these chlamydial species, despite different tissue tropism and disease pathology.

PubMed: 24192348
DOI: 10.1107/S1744309113027371

Experimental method

X-RAY DIFFRACTION (3.051 Å)