4MLF
Crystal structure for the complex of thrombin mutant D102N and hirudin
Summary for 4MLF
Entry DOI | 10.2210/pdb4mlf/pdb |
Related | 1SHH |
Descriptor | Thrombin, Hirudin variant-1, SODIUM ION, ... (7 entities in total) |
Functional Keywords | serine protease, ligand binding, hirudin, thrombin, conformational selection, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 40965.27 |
Authors | Vogt, A.D.,Pozzi, N.,Chen, Z.,Di Cera, E. (deposition date: 2013-09-06, release date: 2013-09-25, Last modification date: 2023-09-20) |
Primary citation | Vogt, A.D.,Pozzi, N.,Chen, Z.,Di Cera, E. Essential role of conformational selection in ligand binding. Biophys.Chem., 186C:13-21, 2014 Cited by PubMed: 24113284DOI: 10.1016/j.bpc.2013.09.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report