4MJO

Human liver fructose-1,6-bisphosphatase(d-fructose-1,6-bisphosphate, 1-phosphohydrolase) (e.c.3.1.3.11) complexed with the allosteric inhibitor 3

Summary for 4MJO

Entry DOI	10.2210/pdb4mjo/pdb
Related	2jjk 2vt5
Descriptor	Fructose-1,6-bisphosphatase 1, N-({4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl}carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide (3 entities in total)
Functional Keywords	allostery, hydrolase (phosphoric monoester), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	299150.63
Authors	Ruf, A.,Joseph, C.,Tetaz, T.,Benz, J. (deposition date: 2013-09-04, release date: 2013-11-06, Last modification date: 2023-09-20)
Primary citation	Cubrilovic, D.,Haap, W.,Barylyuk, K.,Ruf, A.,Badertscher, M.,Gubler, M.,Tetaz, T.,Joseph, C.,Benz, J.,Zenobi, R. Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry. Acs Chem.Biol., 9:218-226, 2014 Cited by PubMed: 24128068 DOI: 10.1021/cb4007002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation