4MI9
Crystal structure of Gpb in complex with SUGAR (N-[(3R)-3-(4-ETHYLPHENYL)BUTANOYL]-BETA-D-GLUCOPYRANOSYLAMINE) (S20)
4MI9 の概要
エントリーDOI | 10.2210/pdb4mi9/pdb |
関連するPDBエントリー | 4MHO 4MHS 4MI3 4MI6 4MIC |
分子名称 | Glycogen phosphorylase, muscle form, N-[(3R)-3-(4-ethylphenyl)butanoyl]-beta-D-glucopyranosylamine (3 entities in total) |
機能のキーワード | alpha and beta protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 95862.44 |
構造登録者 | Kantsadi, A.L.,Chatzileontiadou, D.S.M.,Leonidas, D.D. (登録日: 2013-08-30, 公開日: 2014-07-23, 最終更新日: 2023-12-06) |
主引用文献 | Parmenopoulou, V.,Kantsadi, A.L.,Tsirkone, V.G.,Chatzileontiadou, D.S.,Manta, S.,Zographos, S.E.,Molfeta, C.,Archontis, G.,Agius, L.,Hayes, J.M.,Leonidas, D.D.,Komiotis, D. Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines. Bioorg.Med.Chem., 22:4810-4825, 2014 Cited by PubMed: 25092521DOI: 10.1016/j.bmc.2014.06.058 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.85 Å) |
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