4MI5

Crystal structure of the EZH2 SET domain

Summary for 4MI5

Entry DOI	10.2210/pdb4mi5/pdb
Descriptor	Histone-lysine N-methyltransferase EZH2, SULFATE ION, ZINC ION, ... (4 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q15910
Total number of polymer chains	1
Total formula weight	26460.17
Authors	Antonysamy, S.,Condon, B.,Druzina, Z.,Bonanno, J.,Gheyi, T.,Macewan, I.,Zhang, A.,Ashok, S.,Russell, M.,Luz, J.G. (deposition date: 2013-08-30, release date: 2014-01-08, Last modification date: 2024-02-28)
Primary citation	Antonysamy, S.,Condon, B.,Druzina, Z.,Bonanno, J.B.,Gheyi, T.,Zhang, F.,Macewan, I.,Zhang, A.,Ashok, S.,Rodgers, L.,Russell, M.,Gately Luz, J. Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain. Plos One, 8:e84147-e84147, 2013 Cited by PubMed: 24367637 DOI: 10.1371/journal.pone.0084147 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation