4MDR
Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)
Summary for 4MDR
Entry DOI | 10.2210/pdb4mdr/pdb |
Related | 3L81 |
Descriptor | AP-4 complex subunit mu-1, Amyloid beta A4 protein (3 entities in total) |
Functional Keywords | immunoglobulin-like beta-sandwich, adaptor protein complex, golgi apparatus, sorting signal recognition, alzheimer's disease, amyloid precursor protein, protein transport-protein binding complex, protein transport/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Golgi apparatus, trans-Golgi network: O00189 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 2 |
Total formula weight | 34372.03 |
Authors | Ross, B.H.,Lin, Y.,Corales, E.A.,Burgos, P.V.,Mardones, G.A. (deposition date: 2013-08-23, release date: 2014-03-12, Last modification date: 2023-09-20) |
Primary citation | Ross, B.H.,Lin, Y.,Corales, E.A.,Burgos, P.V.,Mardones, G.A. Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4. Plos One, 9:e88147-e88147, 2014 Cited by PubMed: 24498434DOI: 10.1371/journal.pone.0088147 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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