4MDQ
Structure of a novel submicromolar MDM2 inhibitor
Summary for 4MDQ
Entry DOI | 10.2210/pdb4mdq/pdb |
Related | 4MDN |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide (3 entities in total) |
Functional Keywords | mdm2, p53, cancer, small molecule, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 11147.95 |
Authors | Bista, M.,Popowicz, G.,Holak, T.A. (deposition date: 2013-08-23, release date: 2013-11-13, Last modification date: 2024-02-28) |
Primary citation | Bista, M.,Wolf, S.,Khoury, K.,Kowalska, K.,Huang, Y.,Wrona, E.,Arciniega, M.,Popowicz, G.M.,Holak, T.A.,Domling, A. Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. Structure, 21:2143-2151, 2013 Cited by PubMed: 24207125DOI: 10.1016/j.str.2013.09.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.119 Å) |
Structure validation
Download full validation report