4MDE
Structure of bacterial polynucleotide kinase product complex bound to GDP and DNA
Summary for 4MDE
Entry DOI | 10.2210/pdb4mde/pdb |
Related | 4GP6 4GP7 4JST 4JSY 4JT2 4JT4 4MDF |
Descriptor | Metallophosphoesterase, DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | rna repair, p-loop phosphotransferase, transferase, hydrolase-dna complex, transferase-dna complex, transferase/dna |
Biological source | Clostridium thermocellum More |
Total number of polymer chains | 4 |
Total formula weight | 42851.66 |
Authors | Shuman, S.,Das, U.,Wang, L.K.,Smith, P.,Jacewicz, A. (deposition date: 2013-08-22, release date: 2013-11-06, Last modification date: 2024-02-28) |
Primary citation | Das, U.,Wang, L.K.,Smith, P.,Jacewicz, A.,Shuman, S. Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42:1152-1161, 2014 Cited by PubMed: 24150947DOI: 10.1093/nar/gkt936 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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