4MDE

Structure of bacterial polynucleotide kinase product complex bound to GDP and DNA

4MDE の概要

• エントリーDOI: 10.2210/pdb4mde/pdb
• 関連するPDBエントリー: 4GP6 4GP7 4JST 4JSY 4JT2 4JT4 4MDF
• 分子名称: Metallophosphoesterase, DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: rna repair, p-loop phosphotransferase, transferase, hydrolase-dna complex, transferase-dna complex, transferase/dna
• 由来する生物種: Clostridium thermocellum; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 42851.66

構造登録者

Shuman, S.,Das, U.,Wang, L.K.,Smith, P.,Jacewicz, A. (登録日: 2013-08-22, 公開日: 2013-11-06, 最終更新日: 2024-02-28)

• 主引用文献: Das, U.,Wang, L.K.,Smith, P.,Jacewicz, A.,Shuman, S.; Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition.; Nucleic Acids Res., 42:1152-1161, 2014; PubMed: 24150947; DOI: 10.1093/nar/gkt936

実験手法

X-RAY DIFFRACTION (1.8 Å)