4MDD

Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12

Summary for 4MDD

• Entry DOI: 10.2210/pdb4mdd/pdb
• Descriptor: Glucocorticoid receptor, Nuclear receptor corepressor 1, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, ... (4 entities in total)
• Functional Keywords: nuclear hormone receptor ligand binding domain, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform Beta: Nucleus: P04150; Nucleus : O75376
• Total number of polymer chains: 4
• Total formula weight: 63617.76

Authors

Coghlan, M.J.,Luz, J.G. (deposition date: 2013-08-22, release date: 2014-12-03, Last modification date: 2024-02-28)

• Primary citation: Luz, J.G.,Coghlan, M.J.; Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)