4MDD

Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12

4MDD の概要

• エントリーDOI: 10.2210/pdb4mdd/pdb
• 分子名称: Glucocorticoid receptor, Nuclear receptor corepressor 1, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, ... (4 entities in total)
• 機能のキーワード: nuclear hormone receptor ligand binding domain, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm. Isoform Beta: Nucleus: P04150; Nucleus : O75376
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63617.76

構造登録者

Coghlan, M.J.,Luz, J.G. (登録日: 2013-08-22, 公開日: 2014-12-03, 最終更新日: 2024-02-28)

• 主引用文献: Luz, J.G.,Coghlan, M.J.; Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12; To be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)