4MD6

Crystal structure of PDE5 in complex with inhibitor 5R

4MD6 の概要

• エントリーDOI: 10.2210/pdb4md6/pdb
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, ... (6 entities in total)
• 機能のキーワード: protein-inhibitor complex, phosphodiesterase, pde5 inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38347.73

構造登録者

Cui, W.,Huang, M.,Shao, Y.,Luo, H. (登録日: 2013-08-22, 公開日: 2014-07-09)

• 主引用文献: Shang, N.N.,Shao, Y.X.,Cai, Y.H.,Guan, M.,Huang, M.,Cui, W.,He, L.,Yu, Y.J.,Huang, L.,Li, Z.,Bu, X.Z.,Ke, H.,Luo, H.B.; Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.; Biochem Pharmacol, 89:86-98, 2014; PubMed: 24565909; DOI: 10.1016/j.bcp.2014.02.013

実験手法

X-RAY DIFFRACTION (2 Å)