4MCS

A high resolution structure of human glutamate carboxypeptidase II (GCPII) His475Tyr variant in complex with glutamic acid

4MCS の概要

• エントリーDOI: 10.2210/pdb4mcs/pdb
• 関連するPDBエントリー: 4MCP 4MCQ 4MCR
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: zinc metallopeptidase, gcpii, prostate specific membrane antigen, folate hydrolase 1, folh1, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 88228.07

構造登録者

Ptacek, J.,Barinka, C.,Sacha, P.,Navratil, M. (登録日: 2013-08-21, 公開日: 2014-06-18, 最終更新日: 2020-07-29)

• 主引用文献: Navratil, M.,Ptacek, J.,Sacha, P.,Starkova, J.,Lubkowski, J.,Barinka, C.,Konvalinka, J.; Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.; Febs J., 281:3228-3242, 2014; PubMed: 24863754; DOI: 10.1111/febs.12857

実験手法

X-RAY DIFFRACTION (1.83 Å)