4MCB
H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE
Summary for 4MCB
Entry DOI | 10.2210/pdb4mcb/pdb |
Related | 4MCC |
Descriptor | tRNA (guanine-N(1)-)-methyltransferase, GLYCEROL, SULFATE ION, ... (6 entities in total) |
Functional Keywords | trefoil, trmd, sam, sah, sinefungin, hmt, structural genomics, trefoil knot, methyl transferase to trna, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Haemophilus influenzae |
Cellular location | Cytoplasm (Potential): P43912 |
Total number of polymer chains | 2 |
Total formula weight | 56289.46 |
Authors | Olivier, N.B.,Hill, P. (deposition date: 2013-08-21, release date: 2013-09-04, Last modification date: 2024-02-28) |
Primary citation | Hill, P.J.,Abibi, A.,Albert, R.,Andrews, B.,Gagnon, M.M.,Gao, N.,Grebe, T.,Hajec, L.I.,Huang, J.,Livchak, S.,Lahiri, S.D.,McKinney, D.C.,Thresher, J.,Wang, H.,Olivier, N.,Buurman, E.T. Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain. J.Med.Chem., 56:7278-7288, 2013 Cited by PubMed: 23981144DOI: 10.1021/jm400718n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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