4MBL
Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors
Summary for 4MBL
| Entry DOI | 10.2210/pdb4mbl/pdb |
| Related | 4MBI |
| Descriptor | Serine/threonine-protein kinase pim-1, (1R,2R)-N-[3-(naphthalen-2-yl)pyrazolo[1,5-a]pyrimidin-5-yl]cyclohexane-1,2-diamine (2 entities in total) |
| Functional Keywords | kinase, pim1, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
| Total number of polymer chains | 1 |
| Total formula weight | 34203.80 |
| Authors | Azevedo, R.,Fischmann, T.O. (deposition date: 2013-08-19, release date: 2013-09-11, Last modification date: 2024-02-28) |
| Primary citation | Dwyer, M.P.,Keertikar, K.,Paruch, K.,Alvarez, C.,Labroli, M.,Poker, C.,Fischmann, T.O.,Mayer-Ezell, R.,Bond, R.,Wang, Y.,Azevedo, R.,Guzi, T.J. Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach. Bioorg.Med.Chem.Lett., 23:6178-6182, 2013 Cited by PubMed: 24091081DOI: 10.1016/j.bmcl.2013.08.110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report
