4MBF

Crystal structure of Penam sulfone PSR-4-157 bound to SHV-1 beta-lactamase

Summary for 4MBF

• Entry DOI: 10.2210/pdb4mbf/pdb
• Related: 2H5S 4MBH 4MBK
• Descriptor: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, 6-({(2R,3S)-3-carboxy-2-methyl-3-[(3-oxopropyl)amino]-2-sulfinopropyl}oxy)-6-oxohexanoic acid, ... (4 entities in total)
• Functional Keywords: class a beta-lactamase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30687.02

Authors

Rodkey, E.A.,van den Akker, F. (deposition date: 2013-08-19, release date: 2014-07-30)

• Primary citation: Rodkey, E.A.,Winkler, M.L.,Bethel, C.R.,Pagadala, S.R.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.; Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.; Plos One, 9:e85892-e85892, 2014; PubMed: 24454944; DOI: 10.1371/journal.pone.0085892

Experimental method

X-RAY DIFFRACTION (1.54 Å)