4M8X
GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions
Summary for 4M8X
| Entry DOI | 10.2210/pdb4m8x/pdb |
| Related | 2RKF 2RKG 4M8Y |
| Descriptor | Protease, DIETHYL ({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE (3 entities in total) |
| Functional Keywords | hiv protease, aspartic protease, gs8374, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 2 |
| Total formula weight | 23024.89 |
| Authors | Grantz saskova, K.,Brynda, J.,Rezacova, P.,Kozisek, M.,Konvalinka, J. (deposition date: 2013-08-14, release date: 2014-05-07, Last modification date: 2023-09-20) |
| Primary citation | Grantz Saskova, K.,Kozisek, M.,Stray, K.,de Jong, D.,Rezaova, P.,Brynda, J.,van Maarseveen, N.M.,Nijhuis, M.,Cihlar, T.,Konvalinka, J. GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions. J.Virol., 88:3586-3590, 2014 Cited by PubMed: 24371077DOI: 10.1128/JVI.02688-13 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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