2RKG

HIV-1 PR resistant mutant + LPV

Summary for 2RKG

• Entry DOI: 10.2210/pdb2rkg/pdb
• Related: 2RKF
• Descriptor: PROTEASE RETROPEPSIN, GLYCEROL, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (4 entities in total)
• Functional Keywords: resistence, insertion, hydrolase
• Biological source: human immunodeficiency virus 1 (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 22638.53

Authors

Rezacova, P.,Brynda, J.,Kozisek, M.,Saskova, K.,Konvalinka, J. (deposition date: 2007-10-16, release date: 2008-08-05, Last modification date: 2023-08-30)

• Primary citation: Kozisek, M.,Saskova, K.G.,Rezacova, P.,Brynda, J.,van Maarseveen, N.M.,De Jong, D.,Boucher, C.A.,Kagan, R.M.,Nijhuis, M.,Konvalinka, J.; Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region; J.Virol., 82:5869-5878, 2008; PubMed: 18400858; DOI: 10.1128/JVI.02325-07

Experimental method

X-RAY DIFFRACTION (1.8 Å)