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4M8X

GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE KGQ B 101
ChainResidue
AARG8
AILE50
AHOH122
BASP25
BGLY27
BALA28
BASP29
BASP30
BILE32
BVAL46
BGLY48
AASP25
BGLY49
BILE50
BPRO81
BILE84
BHOH226
BHOH246
AGLY27
AALA28
AASP29
AASP30
AILE32
AGLY48
AGLY49

site_idAC2
Number of Residues23
DetailsBINDING SITE FOR RESIDUE KGQ B 102
ChainResidue
AASP25
AGLY27
AALA28
AASP30
AVAL46
AGLY48
AGLY49
APRO81
AILE84
AHOH122
BLEU23
BASP25
BGLY27
BALA28
BASP29
BASP30
BILE32
BGLY48
BGLY49
BILE50
BPHE53
BHOH226
BHOH247

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTIL
ChainResidueDetails
AALA22-LEU33

221051

PDB entries from 2024-06-12

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