4M7Y

Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog

Summary for 4M7Y

• Entry DOI: 10.2210/pdb4m7y/pdb
• Related: 4M7X
• Descriptor: Type II pantothenate kinase, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-pentyl-beta-alaninamide, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: pantothenate kinase, inhibitor, antibacterial, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Staphylococcus aureus subsp. aureus
• Cellular location: Cytoplasm : Q8NVG0
• Total number of polymer chains: 2
• Total formula weight: 62167.56

Authors

Mottaghi, K.,Hong, B.,Tempel, W.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2013-08-12, release date: 2014-09-03, Last modification date: 2023-09-20)

• Primary citation: Hughes, S.J.,Barnard, L.,Mottaghi, K.,Tempel, W.,Antoshchenko, T.,Hong, B.S.,Allali-Hassani, A.,Smil, D.,Vedadi, M.,Strauss, E.,Park, H.W.; Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.; ACS Infect Dis, 2:627-641, 2016; PubMed: 27759386; DOI: 10.1021/acsinfecdis.6b00090

Experimental method

X-RAY DIFFRACTION (1.8 Å)