4M7V
Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl
Summary for 4M7V
Entry DOI | 10.2210/pdb4m7v/pdb |
Related | 4M7U |
Descriptor | Dihydrofolate reductase, 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, reduction of dihydrofolate to tetrahydrofolate |
Biological source | Enterococcus faecalis |
Total number of polymer chains | 1 |
Total formula weight | 21146.59 |
Authors | Bourne, C.R. (deposition date: 2013-08-12, release date: 2014-03-05, Last modification date: 2023-09-20) |
Primary citation | Bourne, C.R.,Wakeham, N.,Webb, N.,Nammalwar, B.,Bunce, R.A.,Berlin, K.D.,Barrow, W.W. The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking. Biochemistry, 53:1228-1238, 2014 Cited by PubMed: 24495113DOI: 10.1021/bi401104t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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