4M7V

Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl

4M7V の概要

• エントリーDOI: 10.2210/pdb4m7v/pdb
• 関連するPDBエントリー: 4M7U
• 分子名称: Dihydrofolate reductase, 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, reduction of dihydrofolate to tetrahydrofolate
• 由来する生物種: Enterococcus faecalis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21146.59

構造登録者

Bourne, C.R. (登録日: 2013-08-12, 公開日: 2014-03-05, 最終更新日: 2023-09-20)

• 主引用文献: Bourne, C.R.,Wakeham, N.,Webb, N.,Nammalwar, B.,Bunce, R.A.,Berlin, K.D.,Barrow, W.W.; The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking.; Biochemistry, 53:1228-1238, 2014; PubMed: 24495113; DOI: 10.1021/bi401104t

実験手法

X-RAY DIFFRACTION (2.3 Å)