4M6J
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH
Summary for 4M6J
Entry DOI | 10.2210/pdb4m6j/pdb |
Related | 4M6K 4M6L |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
Functional Keywords | rossmann fold, nadph binding, folate binding, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22226.14 |
Authors | Bhabha, G.,Ekiert, D.C.,Wright, P.E.,Wilson, I.A. (deposition date: 2013-08-09, release date: 2013-09-25, Last modification date: 2023-09-20) |
Primary citation | Bhabha, G.,Ekiert, D.C.,Jennewein, M.,Zmasek, C.M.,Tuttle, L.M.,Kroon, G.,Dyson, H.J.,Godzik, A.,Wilson, I.A.,Wright, P.E. Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20:1243-1249, 2013 Cited by PubMed: 24077226DOI: 10.1038/nsmb.2676 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.201 Å) |
Structure validation
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