4M5N
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
4M5N の概要
エントリーDOI | 10.2210/pdb4m5n/pdb |
関連するPDBエントリー | 1HKA 1KBR 1Q0N 4M5G 4M5H 4M5I 4M5J 4M5K 4M5L 4M5M |
分子名称 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (5 entities in total) |
機能のキーワード | folate biosynthesis, diphosphotransferases, pterin, atp binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Escherichia coli |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 38202.04 |
構造登録者 | Yun, M.,Hoagland, D.,Kumar, G.,Waddell, B.,Rock, C.O.,Lee, R.E.,White, S.W. (登録日: 2013-08-08, 公開日: 2014-04-02, 最終更新日: 2023-09-20) |
主引用文献 | Yun, M.K.,Hoagland, D.,Kumar, G.,Waddell, M.B.,Rock, C.O.,Lee, R.E.,White, S.W. The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22:2157-2165, 2014 Cited by PubMed: 24613625DOI: 10.1016/j.bmc.2014.02.022 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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