Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | MG502 |
| A | APC503 |
| A | HOH603 |
| A | HOH604 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | APC503 |
| A | HOH601 |
| A | HOH602 |
| A | ASP95 |
| A | ASP97 |
| A | MG501 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE APC A 503 |
| Chain | Residue |
| A | GLN74 |
| A | ARG82 |
| A | ARG88 |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| A | LEU111 |
| A | THR112 |
| A | HIS115 |
| A | TYR116 |
| A | ARG121 |
| A | MG501 |
| A | MG502 |
| A | HOH601 |
| A | HOH602 |
| A | HOH603 |
| A | HOH604 |
| A | HOH605 |
| A | HOH606 |
| A | HOH608 |
| A | HOH609 |
| A | HOH610 |
| A | HOH614 |
| A | HOH688 |
| A | HOH689 |
| A | HOH740 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE YH7 A 504 |
| Chain | Residue |
| A | THR42 |
| A | PRO43 |
| A | PRO44 |
| A | LEU45 |
| A | TYR53 |
| A | ASN55 |
| A | TRP89 |
| A | ARG92 |
| A | ASP95 |
| A | PHE123 |
| A | HOH615 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 201 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | MG202 |
| B | APC203 |
| B | HOH341 |
| B | HOH342 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | MG201 |
| B | APC203 |
| B | HOH309 |
| B | HOH373 |
| site_id | AC7 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE APC B 203 |
| Chain | Residue |
| B | GLN74 |
| B | ARG82 |
| B | ARG88 |
| B | ARG92 |
| B | ASP95 |
| B | ASP97 |
| B | ILE98 |
| B | ARG110 |
| B | LEU111 |
| B | THR112 |
| B | HIS115 |
| B | TYR116 |
| B | ARG121 |
| B | MG201 |
| B | MG202 |
| B | HOH307 |
| B | HOH308 |
| B | HOH309 |
| B | HOH310 |
| B | HOH314 |
| B | HOH342 |
| B | HOH373 |
| B | HOH374 |
| B | HOH376 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE YH7 B 204 |
| Chain | Residue |
| B | THR42 |
| B | PRO43 |
| B | PRO44 |
| B | LEU45 |
| B | TYR53 |
| B | ASN55 |
| B | TRP89 |
| B | ARG92 |
| B | ASP95 |
| B | PHE123 |
| B | HOH343 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG88-MET99 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP95 | metal ligand |
| A | ASP97 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| B | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| B | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP95 | metal ligand |
| B | ASP97 | metal ligand |
