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4M5J

The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

Summary for 4M5J
Entry DOI10.2210/pdb4m5j/pdb
Related1HKA 1KBR 1Q0N 4M5G 4M5H 4M5I 4M5K 4M5L 4M5M 4M5N
Descriptor2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, 2-amino-8-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, ... (6 entities in total)
Functional Keywordsfolate biosynthesis, diphosphotransferases, pterin, atp binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight19336.08
Authors
Yun, M.,Hoagland, D.,Kumar, G.,Waddell, B.,Rock, C.O.,Lee, R.E.,White, S.W. (deposition date: 2013-08-08, release date: 2014-04-02, Last modification date: 2023-09-20)
Primary citationYun, M.K.,Hoagland, D.,Kumar, G.,Waddell, M.B.,Rock, C.O.,Lee, R.E.,White, S.W.
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22:2157-2165, 2014
Cited by
PubMed: 24613625
DOI: 10.1016/j.bmc.2014.02.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.696 Å)
Structure validation

217705

건을2024-03-27부터공개중

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