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4M4B

Human Hemoglobin Nitroethane Modified

Summary for 4M4B
Entry DOI10.2210/pdb4m4b/pdb
Related4M4A
DescriptorHemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywordsr-state, human hemoglobin, nitroethane modified, oxygen transport
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight32424.69
Authors
Yi, J.,Thomas, L.M.,Richter-Addo, G.B. (deposition date: 2013-08-06, release date: 2014-07-16, Last modification date: 2023-09-20)
Primary citationYi, J.,Ye, G.,Thomas, L.M.,Richter-Addo, G.B.
Degradation of human hemoglobin by organic C-nitroso compounds.
Chem.Commun.(Camb.), 49:11179-11181, 2013
Cited by
PubMed Abstract: The crystal structure of the nitrosomethane adduct of human Hb shows N-binding of the MeNO ligands to heme Fe. The structure of the EtNO adduct reveals a surprising 4.9 Å heme slippage in the β subunit, and explains the ability of C-nitroso compounds to degrade Hb removing it from circulation.
PubMed: 24149619
DOI: 10.1039/c3cc46174b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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