4M49

Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18

4M49 の概要

• エントリーDOI: 10.2210/pdb4m49/pdb
• 関連するPDBエントリー: 4JNK
• 分子名称: L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: dehydrogenase/reductase, nicotinamide adenine dinucleotide nadh, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00338
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151275.29

構造登録者

Eigenbrot, C.,Ultsch, M. (登録日: 2013-08-06, 公開日: 2013-09-04, 最終更新日: 2023-11-15)

• 主引用文献: Fauber, B.P.,Dragovich, P.S.,Chen, J.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Giannetti, A.M.,Hunsaker, T.,Labadie, S.,Liu, Y.,Liu, Y.,Malek, S.,Peterson, D.,Pitts, K.,Sideris, S.,Ultsch, M.,Vanderporten, E.,Wang, J.,Wei, B.,Yen, I.,Yue, Q.; Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.; Bioorg.Med.Chem.Lett., 23:5533-5539, 2013; PubMed: 24012183; DOI: 10.1016/j.bmcl.2013.08.060

実験手法

X-RAY DIFFRACTION (2.052 Å)