4M3M

Influenza Neuraminidase in complex with a stereomutated analogue of Oseltamivir carboxylate

Summary for 4M3M

• Entry DOI: 10.2210/pdb4m3m/pdb
• Descriptor: Neuraminidase, (3R,4S,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: sialidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Cellular location: Host apical cell membrane ; Single-pass type II membrane protein : Q0A480
• Total number of polymer chains: 1
• Total formula weight: 43668.16

Authors

Kerry, P.S. (deposition date: 2013-08-06, release date: 2014-02-12, Last modification date: 2020-07-29)

• Primary citation: Sartori, A.,Dell'amico, L.,Battistini, L.,Curti, C.,Rivara, S.,Pala, D.,Kerry, P.S.,Pelosi, G.,Casiraghi, G.,Rassu, G.,Zanardi, F.; Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate.; Org.Biomol.Chem., 12:1561-1569, 2014; PubMed: 24425043; DOI: 10.1039/c3ob42069h

Experimental method

X-RAY DIFFRACTION (2.1 Å)