4M2X

Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)

4M2X の概要

• エントリーDOI: 10.2210/pdb4m2x/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (6 entities in total)
• 機能のキーワード: structural genomics, tb structural genomics consortium, tbsgc, reductase, nadph binding, hydride transfer, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77630.41

構造登録者

Jung, H.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2013-08-05, 公開日: 2014-11-12, 最終更新日: 2024-02-28)

• 主引用文献: Jung, H.,Sacchettini, J.C.; Selective inhibitors for dihydrofolate reductase from mycobacterium tuberculosis; To be Published,

実験手法

X-RAY DIFFRACTION (2.26 Å)