4M0R

Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD).

4M0R の概要

• エントリーDOI: 10.2210/pdb4m0r/pdb
• 関連するPDBエントリー: 4GIU 4GKM 4IJ1
• 分子名称: Anthranilate phosphoribosyltransferase, 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: magnesium binding, phosphoribosylpyrophosphate, prpp, inhibitor complex, tri-anthranilate analogue, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78998.19

構造登録者

Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2013-08-02, 公開日: 2014-05-21, 最終更新日: 2023-09-20)

• 主引用文献: Evans, G.L.,Gamage, S.A.,Bulloch, E.M.,Baker, E.N.,Denny, W.A.,Lott, J.S.; Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.; Chembiochem, 15:852-864, 2014; PubMed: 24623674; DOI: 10.1002/cbic.201300628

実験手法

X-RAY DIFFRACTION (1.96 Å)