4LZS

Crystal Structure of BRD4(1) bound to inhibitor XD46

Summary for 4LZS

Entry DOI	10.2210/pdb4lzs/pdb
Related	4LYI 4LYS 4LYW 4LZR
Descriptor	Bromodomain-containing protein 4, 4-acetyl-3-ethyl-N,5-dimethyl-1H-pyrrole-2-carboxamide (3 entities in total)
Functional Keywords	brd4 inhibitor, bromodomain, epigenetic reader protein, acetylated lysine, histone tail, nucleus, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15307.64
Authors	Wohlwend, D.,Huegle, M.,Einsle, O.,Gerhardt, S. (deposition date: 2013-08-01, release date: 2014-01-15, Last modification date: 2024-02-28)
Primary citation	Lucas, X.,Wohlwend, D.,Hugle, M.,Schmidtkunz, K.,Gerhardt, S.,Schule, R.,Jung, M.,Einsle, O.,Gunther, S. 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52:14055-14059, 2013 Cited by PubMed: 24272870 DOI: 10.1002/anie.201307652 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation