4LZ8

Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators

Summary for 4LZ8

• Entry DOI: 10.2210/pdb4lz8/pdb
• Related: 4LZ5 4LZ7
• Descriptor: Glutamate receptor 2, GLUTAMIC ACID, N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide, ... (5 entities in total)
• Functional Keywords: ampa receptor, allosteric modulator, transport protein
• Biological source: Rattus norvegicus (brown rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 3
• Total formula weight: 92652.96

Authors

Pandit, J. (deposition date: 2013-07-31, release date: 2013-12-04, Last modification date: 2023-09-20)

• Primary citation: Patel, N.C.,Schwarz, J.,Hou, X.J.,Hoover, D.J.,Xie, L.,Fliri, A.J.,Gallaschun, R.J.,Lazzaro, J.T.,Bryce, D.K.,Hoffmann, W.E.,Hanks, A.N.,McGinnis, D.,Marr, E.S.,Gazard, J.L.,Hajos, M.,Scialis, R.J.,Hurst, R.S.,Shaffer, C.L.,Pandit, J.,O'Donnell, C.J.; Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.; J.Med.Chem., 56:9180-9191, 2013; PubMed: 24215237; DOI: 10.1021/jm401274b

Experimental method

X-RAY DIFFRACTION (1.85 Å)