4LYF
Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C
Summary for 4LYF
Entry DOI | 10.2210/pdb4lyf/pdb |
Related | 4L8G 4L9S 4L9W 4LPK 4LRW 4LUC 4LV6 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4,5-dichloro-2-hydroxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide, ... (4 entities in total) |
Functional Keywords | gtpase, gdp bound, small molecule inhibitor, covalent binder, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 3 |
Total formula weight | 59798.27 |
Authors | Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. (deposition date: 2013-07-31, release date: 2013-11-27, Last modification date: 2017-11-15) |
Primary citation | Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503:548-551, 2013 Cited by PubMed: 24256730DOI: 10.1038/nature12796 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.568 Å) |
Structure validation
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