4LY9

Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate

Summary for 4LY9

• Entry DOI: 10.2210/pdb4ly9/pdb
• Descriptor: Glucokinase regulatory protein, IODIDE ION, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• Functional Keywords: regulatory protein, disruptor ligand complex, sis domains, gkrp binds to gk, liver, carbohydrate binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): Q14397
• Total number of polymer chains: 2
• Total formula weight: 145766.50

Authors

Jordan, S.R. (deposition date: 2013-07-30, release date: 2013-11-20, Last modification date: 2024-02-28)

• Primary citation: Lloyd, D.J.,St Jean, D.J.,Kurzeja, R.J.,Wahl, R.C.,Michelsen, K.,Cupples, R.,Chen, M.,Wu, J.,Sivits, G.,Helmering, J.,Komorowski, R.,Ashton, K.S.,Pennington, L.D.,Fotsch, C.,Vazir, M.,Chen, K.,Chmait, S.,Zhang, J.,Liu, L.,Norman, M.H.,Andrews, K.L.,Bartberger, M.D.,Van, G.,Galbreath, E.J.,Vonderfecht, S.L.,Wang, M.,Jordan, S.R.,Veniant, M.M.,Hale, C.; Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.; Nature, 504:437-440, 2013; PubMed: 24226772; DOI: 10.1038/nature12724

Experimental method

X-RAY DIFFRACTION (2.35 Å)