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4LXD

Bcl_2-Navitoclax Analog (without Thiophenyl) Complex

Summary for 4LXD
Entry DOI10.2210/pdb4lxd/pdb
Related4LVT 4LXE
DescriptorApoptosis regulator Bcl-2, 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide (3 entities in total)
Functional Keywords8 helices, apoptosis regulator-inhibitor complex, apoptosis regulator/inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationMitochondrion outer membrane ; Single-pass membrane protein : P10415
Total number of polymer chains1
Total formula weight20079.81
Authors
Park, C.H. (deposition date: 2013-07-29, release date: 2013-08-14, Last modification date: 2024-02-28)
Primary citationSouers, A.J.,Leverson, J.D.,Boghaert, E.R.,Ackler, S.L.,Catron, N.D.,Chen, J.,Dayton, B.D.,Ding, H.,Enschede, S.H.,Fairbrother, W.J.,Huang, D.C.,Hymowitz, S.G.,Jin, S.,Khaw, S.L.,Kovar, P.J.,Lam, L.T.,Lee, J.,Maecker, H.L.,Marsh, K.C.,Mason, K.D.,Mitten, M.J.,Nimmer, P.M.,Oleksijew, A.,Park, C.H.,Park, C.M.,Phillips, D.C.,Roberts, A.W.,Sampath, D.,Seymour, J.F.,Smith, M.L.,Sullivan, G.M.,Tahir, S.K.,Tse, C.,Wendt, M.D.,Xiao, Y.,Xue, J.C.,Zhang, H.,Humerickhouse, R.A.,Rosenberg, S.H.,Elmore, S.W.
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19:202-208, 2013
Cited by
PubMed: 23291630
DOI: 10.1038/nm.3048
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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