4LXD
Bcl_2-Navitoclax Analog (without Thiophenyl) Complex
Summary for 4LXD
Entry DOI | 10.2210/pdb4lxd/pdb |
Related | 4LVT 4LXE |
Descriptor | Apoptosis regulator Bcl-2, 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide (3 entities in total) |
Functional Keywords | 8 helices, apoptosis regulator-inhibitor complex, apoptosis regulator/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion outer membrane ; Single-pass membrane protein : P10415 |
Total number of polymer chains | 1 |
Total formula weight | 20079.81 |
Authors | Park, C.H. (deposition date: 2013-07-29, release date: 2013-08-14, Last modification date: 2024-02-28) |
Primary citation | Souers, A.J.,Leverson, J.D.,Boghaert, E.R.,Ackler, S.L.,Catron, N.D.,Chen, J.,Dayton, B.D.,Ding, H.,Enschede, S.H.,Fairbrother, W.J.,Huang, D.C.,Hymowitz, S.G.,Jin, S.,Khaw, S.L.,Kovar, P.J.,Lam, L.T.,Lee, J.,Maecker, H.L.,Marsh, K.C.,Mason, K.D.,Mitten, M.J.,Nimmer, P.M.,Oleksijew, A.,Park, C.H.,Park, C.M.,Phillips, D.C.,Roberts, A.W.,Sampath, D.,Seymour, J.F.,Smith, M.L.,Sullivan, G.M.,Tahir, S.K.,Tse, C.,Wendt, M.D.,Xiao, Y.,Xue, J.C.,Zhang, H.,Humerickhouse, R.A.,Rosenberg, S.H.,Elmore, S.W. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19:202-208, 2013 Cited by PubMed: 23291630DOI: 10.1038/nm.3048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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