4LXB
Crystal Structure Analysis of thrombin in complex with compound D58
Summary for 4LXB
Entry DOI | 10.2210/pdb4lxb/pdb |
Related | 4LOY |
Descriptor | Prothrombin, Thrombin light chain, Hirudin variant-1, Prothrombin, ... (7 entities in total) |
Functional Keywords | serine proteases, antithrombotic agents, dual thrombin/factor xa inhi, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 36455.75 |
Authors | Stehlin-Gaon, C.,Bocskei, Z. (deposition date: 2013-07-29, release date: 2014-06-11, Last modification date: 2020-07-29) |
Primary citation | Meneyrol, J.,Follmann, M.,Lassalle, G.,Wehner, V.,Barre, G.,Rousseaux, T.,Altenburger, J.M.,Petit, F.,Bocskei, Z.,Schreuder, H.,Alet, N.,Herault, J.P.,Millet, L.,Dol, F.,Florian, P.,Schaeffer, P.,Sadoun, F.,Klieber, S.,Briot, C.,Bono, F.,Herbert, J.M. 5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. J.Med.Chem., 56:9441-9456, 2013 Cited by PubMed: 24175584DOI: 10.1021/jm4005835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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